The association between SDF-1 G801A polymorphism and non-small cell lung cancer risk in a Chinese Han population.
نویسندگان
چکیده
BACKGROUND SDF-1 G801A polymorphism is reported to correlate with cancer susceptibility. However, the association between SDF-1 G801A polymorphism and non-small cell lung cancer (NSCLC) risk in Chinese populations remains unknown. MATERIAL AND METHODS A total of 408 NSCLC patients and 303 health controls included in this study. Restriction length fragment polymorphism (RFLP) analysis was used to assess the frequencies of SDF-1 G801A polymorphic variant. RESULTS No significant association was found between SDF-1 G801A polymorphism and NSCLC risk (OR=1.268, 95% CI 0.811-2.583, P=0.361). Furthermore, SDF-1 G801A polymorphism was not correlated with histological type (P=0.697) and TNM stage (P=0.276). CONCLUSION SDF-1 G801A polymorphism was not a risk factor for NSCLC in Chinese Han population.
منابع مشابه
بررسی رابطه پلیمورفیسم در جایگاه اتصال miR-214 در ژن EGFR با سرطان ریه
Background and Aim: Lung cancer is the most common cause of cancer-related deaths wordwide and non-small cell lung cancer (NSCLC), especially adenocarcinoma, is the most common type of lung cancer. Most cases of adenocarcinoma will occur due to KRAS mutations or EGFR mutations and amplifications. The polymorphism rs884225 which is associated with increased EGFR expression is located in the 3'UT...
متن کاملNo association between single nucleotide polymorphisms in pre-mirnas and the risk of gastric cancer in Chinese population
Objective(s): Accumulating evidence has demonstrated that miRNAs contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (GC). Recent studies focused on the four single nucleotide polymorphisms (SNPs) of pre-miRNAs including rs11614913, rs3746444, rs2910164, and rs2292832. It was suggested that these four SNPs were significantly associated with the risk ...
متن کاملAssociation between two functional polymorphisms in the MMP-2 promoter and lung cancer incidence in Asian population: a meta-analysis study
Background: Numerous experiments have been performed to determine the relationship between the Matrix metalloproteinase-2 (MMP-2) -1306C/T and -735C/T polymorphisms and the prevalence and progression of lung cancer in diverse populations. However, due to the small sample size and the different results of previous studies, we decided to perform a general meta-analysis on all previous studies abo...
متن کاملThe CXCL12 G801A Polymorphism Is Associated with Cancer Risk: A Meta-Analysis
BACKGROUND CXCL12 is a small chemotactic cytokine belonging to the CXC chemokine family expressed in various organs. It contributes to the migration, invasion and angiogenesis of cancer cells. Recently, the CXCL12 G801A polymorphism was shown to be associated with an increased risk of various kinds of cancers, but the results were too inconsistent to be conclusive. METHODS To solve the proble...
متن کاملCXCL12-G801A polymorphism modulates risk of colorectal cancer in Taiwan
INTRODUCTION The chemokine CXCL12, designated stromal cell-derived factor-1 (SDF-1), plays a significant role in many cancer metastases. Previous studies have shown that CXCL12-G801A, a single nucleotide polymorphism (SNP) in the 3' untranslated region, correlates with breast and lung cancer in Iran. The aim of this study was to evaluate the association of the gene variant CXCL12-G801A with col...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- International journal of clinical and experimental medicine
دوره 8 8 شماره
صفحات -
تاریخ انتشار 2015